The gameplay is similar to the original, using the Wii remote for all kinds of methods, such as flinging the remote upward for the Chili mini-game or holding the remote still to keep simulate balancing certain items such as the Burger Balance game. There are also musical mini-games that require you to time your movements with the remote and Nunchuk to keep with the beat of the music. Another is a driving game that requires you to move the remote left or right to simulate steering among others.

There are sixty mini-games, including being able to play in co-op or play head-to-head against a friend. There are five different regions to play in including USA, Europe and Asia and there are 110 different items to customize Rayman and the Rabbids with over 540,000 different combinations.